The American Journal of Bioethics, Volume 11, Issue 6, Page 60-62, June 2011.

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

This article presents an overview ofregulations, guidelines and societal debates ineight member states of the EC about a)embryonic and fetal tissue transplantation(EFTT), and b) the use of human embryonic stemcells (hES cells) for research into celltherapy, including `therapeutic' cloning. Thereappears to be a broad acceptance of EFTT inthese countries. In most countries guidance hasbeen developed. There is a `strong' consensusabout some of the central conditions for `goodclinical practice' regarding EFTT.International differences concern, amongstothers, some of the informed consent issuesinvolved, and the (...) questions whether anintermediary organisation is necessary, whetherthe methods of abortion may be influenced bythe possible use of EFT, and whether EFTTshould only be used for the experimentaltreatment of rare disorders. The potential useof hES cells for research into cell therapy hasgiven a new impetus to the debate about (human)embryo research. The therapeutic prospects withregard to the retrieval and research use of hEScells appear to function as a catalyst for theintroduction of less restrictive regulationsconcerning research with spare embryos, atleast in some European countries. It remains tobe seen whether the prospect of treatingpatients suffering from serious disorders withtransplants produced by therapeutic cloningwill decrease the societal and moral resistanceto allowing the generation of embryos for`instrumental' use. (shrink)

On the one hand, much has been written on Theodosius Dobzhansky’s central role in the development of the field of population genetics and modern evolutionary theory, as well as on his sociopolitical worldview in the middle of the Twentieth Century. On the other hand, much has also been written on Dobzhansky’s role in the institutionalization of genetics in Brazil, where he spent a considerable amount of time. Unfortunately, these literatures developed without any points of intersection or cross-reference. This article places (...) Dobzhansky’s work in Brazil in the broader contexts of the science and politics of its historical period. (shrink)

Feelings are conscious mental events that represent body states as they undergo homeostatic regulation. Feelings depend on the interoceptive nervous system (INS), a collection of peripheral and central pathways, nuclei and cortical regions which continuously sense chemical and anatomical changes in the organism. How such humoral and neural signals come to generate conscious mental states has been a major scientific question. The answer proposed here invokes (1) several distinctive and poorly known physiological features of the INS; and (2) a unique (...) interaction between the body (the ‘object’ of interoception) and the central nervous system (which generates the 'subject' of interoception). The atypical traits of the INS and the direct interactions between neural and non‐neural physiological compartments of the organism, neither of which is present in exteroceptive systems, plausibly explain the qualitative and subjective aspects of feelings, thus accounting for their conscious nature. (shrink)

RESUMO A partir do exame da tradição heraclitiana e platônica sobre a transitoriedade e a imortalidade - conceitos compreendidos como universais - este artigo defende a seguinte antinomia como tese: para haver temporalidade é preciso haver eternidade. Essa tese é demonstrada por meio do estudo e atualização das noções de alma, espírito, ideia e memória, as quais estão conectadas invariavelmente ao tempo passado como princípio ontológico do fenômeno histórico. Para além do ponto de vista filosófico, portanto, da perspectiva específica do (...) conhecimento histórico, este estudo expõe algumas implicações teóricas acerca das condições de possibilidade da história, que são discutidas, finalmente, em diálogo com Friedrich Nietzsche e Jacob Burckhardt. ABSTRACT From the analysis of the Heraclitian and Platonic tradition on transience and immortality - understood as universal concepts - this essay defends the following antinomy as its thesis: if there is temporality there must be eternity. This thesis is demonstrated through the study and updating of the notions of soul, spirit, idea and memory, which are invariably connected to the past as the ontological principle of the historical phenomenon. Beyond the philosophical point of view, therefore, from the specific perspective of historical knowledge, this study exposes some theoretical implications about the conditions of possibility of history, which are finally discussed in dialogue with Friedrich Nietzsche and Jacob Burckhardt. (shrink)

O presente trabalho apresenta a segunda parte do artigo onde a figura de Medéia no canto III das Argonáuticas será examinada. A fim de tornar a leitura mais clara e enriquecedora, fez-se necessário tecer alguns comentários sobre a vida e a obra de Apolônio Ródio, autor da obra aqui estudada.

O presente trabalho será dividido em duas partes, a primeira tem por objetivo examinar toda a tradição anterior acerca de Medéia para melhor estudar e compreender a arte de Apolônio Ródio em sua obra épica Argonáuticas. A segunda parte examinará a figura de Medéia no canto III das Argonáuticas.

A presente coletânea é resultado de cooperação de pesquisadores brasileiros e portugueses, envolvidos com a docência no ensino superior e a consequente formação continuada dos professores universitários. A frequência no ensino superior é vista como uma conquista social dos ideais democráticos modernos e teria trazido novos públicos aos bancos escolares, o que tornaria esse ensino uma realidade de maneira qualitativa distinta com a qual decisores políticos, gestores, professores e estudantes devem aprender a lidar. Essas preocupações pretenderam motivar e nortear os (...) temas abordados nesta obra. (shrink)

This book highlights some of the most pressing safety, ethical, legal and societal issues related to the diverse contexts in which robotic technologies apply. Focusing on the essential concept of well-being, it addresses topics that are fundamental not only for research, but also for industry and end-users, discussing the challenges in a wide variety of applications, including domestic robots, autonomous manufacturing, personal care robots and drones.

Sem querer ser uma aproximação histórica e cultural ao tema indicado no título, este artigo visa discutir o seu quadro metafísico a fim de, em diálogo com uma interpretação de Miguel B. Pereira, fazer repercutir tal quadro mais na linhagem futura da análise leibniziana e menos na do apriori kantiano.

No presente artigo pretendemos apresentar o conceito de violência-poder em Walter Benjamin (1892 – 1940), com base no ensaio intitulado Crítica do Poder, Crítica da Violência [Zur Kritik der Gewalt] . Utilizamos como ponto de partida da crítica aqui em questão, a consideração da violência-poder no movimento próprio do texto de Walter Benjamim. Nesse sentido, esta exposição tem a seguinte seqüência: a) A recusa crítica dos pressupostos metodológicos do jusnaturalismo e do positivismo jurídico; b) A definição do procedimento da filosofia (...) da história para estabelecer os critérios para uma avaliação do poder-violência; c) A identificação de dois princípios inerentes ao direito: a violência instauradora da lei ( Rechtsetzende Gewalt ) e a violência mantenedora da lei ( Rechtsendhaltende Gewalt ). A partir daí, estabelecemos as seguintes suspeitas ou hipóteses: 1) O direito ou poder jurídico possui uma forma paradoxal de atuação, segundo as dimensões, instituidora e mantenedora do poder- violência, ou seja, na medida em que ele se faz valer, ele cria a sua própria suspensão, produz a exceção. 2) Essa contradição não se explicita na letra da lei, não se explica pelo seu caráter formal, mas apenas na realidade no sentido histórico abordado por Benjamin. (shrink)

This paper deals with Fichte’s The Characteristics of the Present Age, and in particular with his discussion of the “empty form of knowledge” he claims stands at the centre of the third – i.e. the present – age. Fichte speaks of a fundamental principle that forms the ‘common denominator’ between the third and fourth main epochs. This fundamental principle – the “maxim of comprehensibility” – makes knowledge and comprehension the measure of all that “counts as being valid and as really (...) existing”. But the question arises: How can one and the same principle act as the “unifying concept” for two different “main epochs of human life”? Does this not go directly against Fichte’s claim that two main epochs differ from each other in every respect, precisely because they arise from two entirely different “unifying principles”, and because everything in them must reflect the difference between their “unifying principles”? Fichte’s answer to this question is as follows: a) the fundamental maxim in question allows for two diametrically opposed interpretations, so that each of them provides the principle or the “unifying concept” from which the third and fourth main epochs arise, and b) the third main epoch only gives rise to the empty form of science, as opposed to “truly real science”: it stands for a careless and easy-going, shallow, conventional, trivializing and incorrect conception of the “fundamental maxim of comprehensibility” – so that it misses what is essential, does not do justice to the fundamental maxim, overlooks its implications, and indeed goes against its innermost meaning. Special attention is paid to the question of whether and how some major features of Fichte’s “empty form of knowledge” result from a misguided and superficial understanding of Kant’s “maxims of the self-preservation of reason” and can be reconstructed from this vantage point. (shrink)

O objetivo principal deste artigo é esclarecer como Brentano define a relação entre (a) o conhecimento de nossos próprios fenômenos de consciência e (b) o conhecimento de fenômenos de consciência de outros sujeitos. Por um lado, Brentano argumenta, seguindo a tradição moderna, que o conhecimento dos próprios atos mentais é absolutamente fundamental. Ao mesmo tempo, porém, ele quer mostrar com sua Psicologia do ponto de vista empírico uma clara alternativa ao introspeccionismo. Mostraremos como Brentano busca unir estes dois objetivos e (...) como ele também aderiu a esta linha em sua Psicologia Descritiva. Sua psicologia como um todo pode, portanto, ser entendida como um apelo ao pluralismo epistemológico. (shrink)

The rapidly increasing number of cases of Zika virus and limited understanding of its congenital sequelae (e.g., microcephaly) led to stories of fear and uncertainty across social media and other mass communication networks. In this study, we used techniques generic to netnography, a form of ethnography, using Internet‐based computer‐mediated communications as a source of data to understand the experience and perceptions of families with infants diagnosed with Zika‐related microcephaly. We screened 27 YouTube™ videos published online between October 2015 and July (...) 2016, during which the Zika epidemic started, peaked, and declined. We identified three themes: (a) experiencing the news of a diagnosis of Zika‐associated microcephaly; (b) experiencing feelings and expectations of the ‘imperfect’ child; and (c) seeking to understand microcephaly to care for the child. We found that families experienced distressing feelings of shock, sadness, hopelessness, and pain, while dealing with emerging and sometimes conflicting information being transmitted by news outlets, uncertainty about the child's health, and healthcare providers’ lack of clarity to guide the family members. The ‘unknown’ factor of ZIKA was an additional stressful factor in the experience of the families. (shrink)

Departing from modal logic, Jean-Yves Girard, as a logician interested in philosophy, presented a distinction between essentialism and existentialism in logic. Carlos Lobo reflected about the Girard’s concept to reinterpret the Husserlian Platonism in regard of the status of logical modalities. We start rescuing the notion of modal logic in the Edmund Husserl’s works, especially Formal and Transcendental Logic and First Philosophy. Developing this reflexion, we propose a new contribution to this discussion, reinterpreting the platonic influence in the Husserlian notions (...) of eidos and science, light of some readings of Lee Hardy and Johanna M. Tito. As a conclusion of this dialogue between Husserl and Girard, the method of eidetic variation is presented as a tool to review the idea of science, in a manner consistent with the phenomenological approach. (shrink)

Reconstruiremos a crítica de Olavo de Carvalho à modernidade, à ciência e aos intelectuais públicos, a partir da sua proposta (a) de um dualismo-maniqueísmo ontológico-antropológico sob a forma de autoexclusão de espírito e matéria enquanto representando o drama humano ante o universo e a eternidade, e (b) de uma perspectiva metodológica dinamizada como intuicionismo personalista, privatista, espiritualista e interiorizado, o qual, como postura anti-estrutural e antissistêmica, capacitaria cada indivíduo humano, independentemente de mediações institucionalistas, cientificistas e tecnicistas, a acessar diretamente (...) a Verdade absoluta e a compreender de si por si mesmo a objetividade do mundo e do homem. Em continuidade, explicitaremos exatamente essa correlação, feita por Olavo de Carvalho, entre modernidade, materialismo, ceticismo, relativismo e ideologia, que descamba para uma ciência positivista-perspectivista incapaz de produzir conhecimento objetivo e de gerar princípios e justificação racionais, para o horizonte da história como espaço do ceticismo e do relativismo, para o instrumento da política enquanto dinamizado por ideologias coletivistas e, finalmente, para a ação institucional-social intersubjetiva enquanto anulando o indivíduo. A modernidade como negação da ontoteologia e centralidade de materialismo, ceticismo, relativismo e ideologia, instaura os dois grandes macrossujeitos totalitários hodiernos, conforme Olavo de Carvalho: a academia e o partido de massas. Palavras-Chave: Olavo de Carvalho; Modernidade; Intelectuais Públicos; Materialismo; Ideologia. “Wise according to the flesh”: Olavo de Carvalho’s criticism to public intellectuals Abstract: We intend to reconstruct the Olavo de Carvalho’s criticism to modernity, science and public intellectuals, from his proposal of (a) a ontological-anthropological dualism-manichaeism as mutual exclusion between spirit and matter as representing the human drama before universe and eternity, as well as (b) through a methodological perspective streamlined as personalist, privatized, spiritualist and interiorized intuitionism, which, as an anti-structural and anti-systemic posture, would able each individual, independently of institutionalist, scientist and technicist mediations, to directly access the absolute Truth, and to comprehend from himself and by himself the objectivity of world and man. From this, we will explicit exactly this correlation, constructed by Olavo de Carvalho, of modernity, materialism, skepticism, relativism and ideology, which leads to a positivist-perspectivist science unable to produce objective knowledge and to generate rational principles and justification, to the horizon of history as sphere of skepticism and relativism, to the instrument of politics as streamlined by collectivist ideologies, and finally to the institutional-social intersubjective action as annulling the individual. Now, modernity as negation of ontotheology and the centrality of materialism, skepticism, relativism and ideology institutes the two main totalitarian macro-subjects of our time, according to Olavo de Carvalho: academy and mass party. Key-Words: Olavo de Carvalho; Modernity; Public Intellectuals; Materialism; Ideology. “Sabios según la carne”: la crítica de Olavo de Carvalho a los intelectuales públicos Resumen: Proponemos reconstruir la crítica de Olavo de Carvalho a la modernidad, la ciencia y los intelectuales públicos, a partir de su propuesta (a) de un dualismo-maniqueísmo ontológico-antropológico en forma de autoexclusión entre espíritu y materia como representación del drama humano ante el universo y la eternidad, así como (b) de una perspectiva metodológica dinamizada como intuicionismo personalista, privatista, espiritualista e interiorizado, que, como postura antiestructural y antisistémica, permitiría a cada individuo humano, independientemente de las mediaciones institucionalistas, científicas y técnicas, acceder directamente a la Verdad absoluta y comprender por sí mismo la objetividad del mundo y del hombre. En continuidad, trataremos de explicar exactamente esta correlación, hecha por Olavo de Carvalho, entre modernidad, materialismo, escepticismo, relativismo e ideología, que conduce a una ciencia positivista-perspectivista incapaz de producir conocimiento objetivo y generar principios y justificación racionales, para el horizonte de la historia como espacio de escepticismo y relativismo, para el instrumento de la política dinamizado por ideologías colectivistas y, finalmente, para la acción institucional-social intersubjetiva como anuladora del individuo. Ahora bien, la modernidad como negación de la ontoteología y centralidad del materialismo, el escepticismo, el relativismo y la ideología, establece los dos grandes macro-sujetos totalitarios de nuestro tiempo, según Olavo de Carvalho: la academia y el partido de masas. Palabras-Clave: Olavo de Carvalho; Modernidad; Intelectuales Públicos; Materialismo; Ideología. Data de registro: 03/12/2020 Data de aceite: 15/06/2022. (shrink)

Artigo publicado em 1920, no periódico carioca o A.B.C. Num primeiro momento, o autor volta-se para o contexto brasileiro, mais especificamente para a escola de Recife, em particular para o livro Ensaios de crítica estética, de Álvaro de Carvalho. Num segundo momento, critica enfaticamente a ideia nietzschiana do übermensch, apontando no super-homem um tipo de indivíduo ambicioso, que se vale da força para dominar socialmente, como um arrivista.

In this paper I claim that perceptual discriminatory skills rely on a suitable type of environment as an enabling condition for their exercise. This is because of the constitutive connection between environment and perceptual discriminatory skills, inasmuch as such connection is construed from an ecological approach. The exercise of a discriminatory skill yields knowledge of affordances of objects, properties, or events in the surrounding environment. This is practical knowledge in the first-person perspective. An organism learns to perceive an object by (...) becoming sensitized to its affordances. I call this position ecological disjunctivism. A corollary of this position is that a case of perception and its corresponding case of hallucination—which is similar to the former only in some respects—are different in nature. I show then how the distinguishability problem is addressed by ecological disjunctivism. (shrink)

Modern science developed in the interflow of culture between west and east. Combing of pratice technology with philosophic thoughts formed experimental method. Holistic views contacting atomism produced system theory. System thoughts are applicated in the science and engineering of biosystems, and the cencepts of system biomedicine (Kamada T.1992), systems biology (Zieglgansberger W, Tolle TR.1993), system bioengineering and system genetics (Zeng BJ. 1994) were established. From positive to synthetic thoughts, philosophy have been developed ontology, cosmology, organism theories. Structurity is structure logic (...) system founded on entity, develop, exist axioms, tolerance, adaptation, fluctuate, interweave, transform theorems and integrate, adaptation, construct laws. Structurity be discussed on the cosmos, life, culture system, creation, hologram theories of structure ontology, construct mutation, simi-structure organism and entity emergence, symbol implication. From the relation of structure, function and development, the structurity put forward the cycle, spiral, triangle structure stability patterns of self-organization in structure complement each other and stratification, functional couple and interflow bounds growth, coordinativetransformation and holographic symmetry. (shrink)

What is it like to perceive a feared object? According to a popular neo-Gibsonian theory in psychology, fear biases our perceptions of objects so as to encourage particular kinds of actions: when we are afraid, spiders may be perceived as physically closer than they are in order to promote fleeing. Firestone mounted severe criticisms against this view, arguing that these cases are better explained by non-perceptual biases that operate on accurate perceptions of the external environment. In this paper I will (...) argue that fear might indeed distort our perceptions of the world, but not in the way neo-Gibsonians suppose. In the view I favor, perceptual distortions occur as by-products of fearful attention, a special mode of attention that is part of an orchestrated defensive response that prepares the organism to deal effectively with a threat. To argue for this view I will rely on empirical evidence that fearful attention narrows down the focus of attention and favors processing of local rather than global features of stimuli, which may jointly explain why perceptual distortions might occur in fearful object seeing. This view has consequences not only for empirical investigations in fearful perceptual distortions, but also for an explanation of the intentionality of fear and the phenomenal integration of bodily and intentional elements in fear episodes. (shrink)

Although "the Socratic method" is commonly understood as a style of pedagogy involving cross-questioning between teacher and student, there has long been debate among scholars of ancient philosophy about how this method as attributed to Socrates should be defined or, indeed, whether Socrates can be said to have used any single, uniform method at all distinctive to his way of philosophizing. This volume brings together essays by classicists and philosophers examining this controversy anew. The point of departure for many of (...) those engaged in the debate has been the identification of Socratic method with "the elenchus" as a technique of logical argumentation aimed at refuting an interlocutor, which Gregory Vlastos highlighted in an influential article in 1983. The essays in this volume look again at many of the issues to which Vlastos drew attention but also seek to broaden the discussion well beyond the limits of his formulation. Some contributors question the suitability of the elenchus as a general description of how Socrates engages his interlocutors; others trace the historical origins of the kinds of argumentation Socrates employs; others explore methods in addition to the elenchus that Socrates uses; several propose new ways of thinking about Socratic practices. Eight essays focus on specific dialogues, each examining why Plato has Socrates use the particular methods he does in the context defined by the dialogue. Overall, representing a wide range of approaches in Platonic scholarship, the volume aims to enliven and reorient the debate over Socratic method so as to set a new agenda for future research. Contributors are Hayden W. Ausland, Hugh H. Benson, Thomas C. Brickhouse, Michelle Carpenter, John M. Carvalho, Lloyd P. Gerson, Francisco J. Gonzalez, James H. Lesher, Mark McPherran, Ronald M. Polansky, Gerald A. Press, François Renaud, and W. Thomas Schmid, Nicholas D. Smith, P. Christopher Smith, Harold Tarrant, Joanne B. Waugh, and Charles M. Young. (shrink)

Neste artigo, discutiremos os limites do modelo de estabilização empregado nas operações da Organização das Nações Unidas para construção da paz de longo prazo. Nosso argumento é que a estratégia política da estabilização, por ser baseada no uso robusto da força para combater grupos armados e apoiar governos no restabelecimento da autoridade estatal, acaba perdendo de vista os esforços de resolução dos conflitos, o que, no limite, contribui para o prolongamento da violência. Metodologicamente, o artigo se baseia no estudo do (...) caso do combate ao grupo armado M23 pela MONUSCO na RDC, por meio da análise de dados e documentos que nos permitam avaliar dois aspectos principais: (i) os níveis de violência armada; e (ii) a condução de um processo político de resolução do conflito. (shrink)

Sot︠s︡ialʹnai︠a︡ filosofii︠a︡ -- Evropeĭskai︠a︡ filosofii︠a︡ (vtorai︠a︡ polovina XIX-XX v.): osnovnye shkoly, tradit︠s︡ii i tendent︠s︡ii.

The path to consensus about physicians’ exercise of conscience was not linear. It looped back on itself as new insights illuminated earlier deliberations and in turn led to further insights. In particular, coming to agreement about physicians’ responsibility in regard to referral charted a route through many course corrections.

One of the most pressing questions concerning singular demonstrative mental contents is what makes their content singular: that is to say, what makes it the case that individual objects are the representata of these mental states. Many philosophers have required sophisticated intellectual capacities for singular content to be possible, such as the possession of an elaborate scheme of space and time. A more recent reaction to this strategy proposes to account for singular content solely on the basis of empirical models (...) of visual processing. We believe both sides make good points, and offer an intermediate way of looking into singular content. Our suggestion is that singular content may be traced to psychological capacities to form flexible, abstract representations in the prefrontal cortex. This allows them to be sustained for increasingly longer periods of time and extrapolated beyond the context of perception, thus going beyond lowlevel sensory representations while also falling short of more sophisticated intellectual abilities. (shrink)